Toradol (Ketorolac) Guide: Uses, Dosage, Side Effects & Safety 21 Sep 2025

Toradol (Ketorolac) Guide: Uses, Dosage, Side Effects & Safety

TL;DR

  • Toradol is the brand name for ketorolac, a powerful NSAID used for short‑term severe pain.
  • It’s usually given by injection or tablet for no more than 5 days to avoid serious side effects.
  • Watch for stomach bleeding, kidney problems, and allergic reactions; avoid it if you have ulcers or are pregnant.
  • Take it with food, stay hydrated, and never combine with other NSAIDs or alcohol without doctor approval.

What Is Toradol?

Toradol is the trade name for ketorolac tromethamine, a synthetic non‑steroidal anti‑inflammatory drug (NSAID). Unlike over‑the‑counter painkillers, ketorolac is strong enough to be classified as a “short‑term opioid‑alternative.” It works by blocking cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins-the chemicals that cause pain, fever, and inflammation.

The drug was first approved by the FDA in 1995 for intravenous (IV) use after surgery. Since then, oral tablets, intramuscular (IM) injections, and even a nasal spray have joined the lineup. Because it can cause serious gastrointestinal (GI) and kidney issues, doctors limit its use to 5 days or less.

When and How Is Toradol Used?

Toradol is typically prescribed for acute, moderate‑to‑severe pain that isn’t controlled by milder analgesics. Common scenarios include:

  • Post‑operative pain after major surgery (orthopedic, dental, or abdominal procedures).
  • Severe renal colic or gallbladder attacks when rapid relief is needed.
  • Traumatic injuries that require strong, short‑term pain control.

Because of the risk profile, Toradol is not a first‑line option for chronic conditions like arthritis. It’s also not recommended for patients who need pain management longer than a few days.

Typical dosing guidelines (always follow the prescribing doctor’s instructions):

  1. Adults 18‑64 years: 30mg IV/IM/IN every 6hours, not exceeding 120mg per day.
  2. Adults ≥65 years or with reduced kidney function: 15mg every 6hours, max 60mg per day.
  3. Oral tablets: 10mg every 4-6hours as needed, max 40mg per day.

Remember, the total treatment duration must stay under 5 days. If pain persists beyond that, a different medication class should be considered.

Safety First: Side Effects, Contraindications, and Interactions

Toradol’s potency brings a higher chance of adverse events. Below are the most common and the most serious issues to watch for.

Common side effects (usually mild)

  • Headache
  • Dizziness or light‑headedness
  • Nausea, vomiting, or indigestion
  • Bruising or injection site pain

Serious side effects (require immediate medical attention)

  • GI bleeding or ulcer perforation - black‑tarry stools, vomiting blood.
  • Kidney failure - reduced urine output, swelling, fatigue.
  • Severe allergic reaction - rash, itching, swelling of face or throat, difficulty breathing.
  • Elevated blood pressure or heart attack risk - chest pain, shortness of breath.

Who Should Not Take Toradol?

  • Anyone with a history of peptic ulcer disease or GI bleeding.
  • Patients with severe renal impairment (creatinine clearance <30mL/min).
  • Pregnant women in the third trimester - it can harm the fetus.
  • People on chronic anticoagulation therapy (warfarin, DOACs) without close monitoring.

Drug Interactions to Keep an Eye On

MedicationInteractionResult
Other NSAIDs (ibuprofen, naproxen)Additive GI/renal toxicityHigher risk of bleeding and kidney damage
Anticoagulants (warfarin, apixaban)Potentiated bleedingIncreased risk of severe hemorrhage
Selective serotonin reuptake inhibitors (SSRIs)Enhanced platelet inhibitionMore likely GI bleeding
ACE inhibitors / ARBsReduced kidney perfusionPotential acute kidney injury

Always list every prescription, OTC, and herbal product you’re taking before starting Toradol.

Practical Tips for Managing Pain with Toradol

Practical Tips for Managing Pain with Toradol

  • Take it with food or milk. This helps buffer the stomach lining and reduces nausea.
  • Stay well‑hydrated, especially if you’re on the IV form. Dehydration raises the chance of kidney problems.
  • Avoid alcohol while on Toradol. Even a small amount can tip the balance toward stomach bleeding.
  • Never combine Toradol with aspirin or other NSAIDs unless your doctor says it’s safe.
  • If you miss a dose (oral route), take it as soon as you remember-unless it’s almost time for the next dose. Never double‑dose.
  • Watch your blood pressure. If you notice a sudden rise, contact your healthcare provider.

For those who need longer‑lasting pain control, discuss alternatives like low‑dose opioids, muscle relaxants, or nerve‑block injections with your doctor. Switching early can prevent the complications associated with prolonged Toradol use.

Frequently Asked Questions

Can I use Toradol after dental surgery?
Yes, many dentists prescribe a short course of IV or oral ketorolac for post‑extraction pain, but only for up to 5 days.
Is Toradol safe for kids?
Toradol is not recommended for children under 17 years of age because the risk of serious side effects outweighs the benefits.
How quickly does it work?
IV or IM administration can begin pain relief within 30minutes; oral tablets usually take 60‑90minutes.
What should I do if I notice black stools?
Stop the medication immediately and seek emergency care-black stools can signal dangerous GI bleeding.
Can I take Toradol if I have high blood pressure?
It’s a caution. NSAIDs can raise blood pressure, so your doctor may monitor you closely or choose another analgesic.

Next Steps & Troubleshooting

If you’ve been prescribed Toradol and are unsure about any aspect, follow these steps:

  1. Read the medication guide that comes with the prescription.
  2. Write down any other drugs, supplements, or herbal products you take.
  3. Ask your pharmacist to point out red‑flag symptoms (e.g., stomach pain, blood in urine).
  4. Set a reminder for the last day you’re allowed to take it-no extensions without a new assessment.
  5. If side effects appear, contact your provider right away. In many cases, they’ll switch you to a safer alternative.

Remember, Toradol is a valuable tool for short‑term pain when used correctly. Respect the dosing limits, watch for warning signs, and keep an open line with your healthcare team.

Drug Typical Dose Onset of Relief Max Duration of Use Key Contraindications
Toradol (ketorolac) 30mg IV/IM q6h or 10mg PO q4‑6h 30‑60min (IV), 60‑90min (PO) ≤5 days Peptic ulcer, renal failure, pregnancy (3rd trimester)
Ibuprofen 200‑400mg PO q6‑8h 30‑60min Up to 10 days OTC, longer with prescription Severe heart failure, active bleeding
Celecoxib (Celebrex) 200mg PO q12h 1‑2h Varies; chronic use possible Sulfa allergy, severe hepatic disease